Health is a necessity for every human being, therefore JKN KIS health insurance is very important for the people oflndonesia, especially Sorong City. Sele Be Solu Hospital is the only city-owned hospital in the Sorong City area. By Karen. the role and function of Sele Be Solu Regional Hospital became very fundamental. However. in reality many patients were not satisfied with the quality of services provided by the management of Sele Be Solu Hospital. The purpose of this study was to analyze the effect of service quality and patient satisfaction on the outpatient loyalty of JKN KIS users in Sele Be Solu Hospital in Sorong City. This research was conducted on outpatients JKN KIS users in Sele Be Solu District Hospital. The total population of outpatients of JKN KIS users during 2018 was 27,789 patients. The technique of determining the sample using probability sampling techniques. While the sample used by researchers was I 00 outpatients JKN KIS users. The independent variable in this study is service quality and customer satisfaction, while the dependent variable is patient loyalty. Variable measurements are carried out using a Likert scale. Data analysis uses multiple regression analysis. Hypothesis testing in this study uses the coefficient of determination test (R2), simultaneous significant test (statistical test F), and significant parameter test of individual parameters (statistical test t). The results of the study with the help of the SPSS program show the Coefficients table t count <t table (-0.521 <l.984). Meaning HI: There is an influence of service quality (Xl) on patient loyalty (Y) outpatients JKN KIS users in Sele Be Solu Hospital Sorong City stated otherwise. From the Coefficients table, the value oft arithmetic = 2.235, which means t arithmetic> t table (2.235> 1.984). Meaning H2: there is an influence of customer satisfaction (X2) on patient loyalty (Y) of outpatient JKN KIS users at Sele Be Solu Hospital in Sorong City, which is proven. The coefficient determination determination R2, the total percentage of variation in the dependent variable explained by the independent variable is 0.086 or 8.6%. This means that the influence of the independent variable (variable service quality and customer satisfaction) on the dependent variable (patient loyalty) is 8.6%. The rest is influenced by other factors outside this study. Simultaneous Significant Test Results (F test) shows the results of the F test calculation with an F value of 4.540> F table 3.09, meaning H3: There is an influence between the quality of service (Xl) and patient satisfaction (X2) on patient loyalty (Y) outpatient JKN KIS users in Sele Be Solu City Hospital in Sorong have been proven proven. So there is a significant and positive influence between the quality of service (Xl) and patient satisfaction (X2) on patient loyalty (Y) outpatient JKN KIS users at Sele Be Solu Hospital Sorong City.